Gabapentin vs Lyrica: Which one is effective to treat neuropathic pain

Gabapentin vs Lyrica: Which one is effective to treat neuropathic pain


Gabapentin and Lyrica are both anticonvulsants that are used to treat neuropathic pain and epilepsy. Both the drugs are chemically related to each other and thus have the same working mechanism in our body i.e inhibiting the flow of certain compounds in our nervous system. Because of the working of the drugs in our body and application, the two medications are listed as one of the most commonly prescribed medications in the USA with more than 60 million prescriptions. However, a question always remains in minds of people that out of the two which is better medication. Here we will provide the answer to that question by discussing and comparing various aspects of both the drugs like working, uses, side effects, and others. Read the section to find out which drug is better or when to use it.

Working mechanism of Gabapentin and Lyrica

Gabapentin and Lyrica (Pregabalin) belong to the class Gabapentinoids which are the derivative of GABA (a natural substance found in our body). Both the medicine works on our central nervous system by inhibiting various calcium channels in our body. However, there is a slight difference in the working of both the drug, as Gabapentin is known to affect the level of the various neurotransmitters, Pregabalin has no known activity on other neurotransmitters like serotonin, dopamine, opiate receptors or any other activity.

Gabapentin vs Lyrica: Side effects of both the medication

Gabapentin and Lyrica, both medications belong to the class Gabapentinoid which is equally effective in treating seizures and neuropathic pain. However, both the medications have drawbacks in the side effects and interaction in our bodies. Some of the side effects caused by both the medication are listed below:

Gabapentin Side effects:

  • Dizziness
  • Fatigue
  • Diplopia
  • Asthenia
  • Constipation
  • Headache
  • Abnormal Thinking
  • Weight Gain
  • Back Pain
  • Impotence
  • Depression

Lyrica side effects

  • Nausea
  • Headache
  • Insomnia
  • Nervousness
  • Irritability
  • Diarrhea

Apart from the side effects, the medications should be avoided in pregnant women and nursing mothers as there can be a chance of passage of the medication from the mother to the baby. Also as both, the medication works on our Central Nervous System, an overdose can be something to look for as CNS depressants have a potential for drug abuse and can create physical dependency of our body on them.

Gabapentin vs Lyrica: Which is more effective

From the above studies, we can say that both the medications, Gabapentin and Parageblin are equally efficacious as they have the same working mechanism. However, from different studies, it is concluded that Gabapentin is more effective as the side effects of the medication are less momentous than those of Lyrica. However, which medication is more effective can only be determined by the condition of the patients. Thus both medications are equally effective based on the condition of the person.

Where can I get Gabapentin and Lyrica online

You can easily buy Gabapentin online or purchase Lyrica online from any pharma store, however, you need to have a prescription first as Gabapentin is a schedule IV drug that you cannot purchase without a prescription. The reason for this can be the misuse of Gabapentinoid medicine for recreational purposes and to avoid various side effects in case of an overdose of the medicine. You can purchase Gabapentin online or order Lyrica online from our pharmacy store which sells genuine medication at reasonable discounted prices. From our store, you can also order Gabapentin COD in which you can pay in cash only after you receive the medication.

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